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The U.S. Food and Drug Administration has approved the use of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to aid manage chronic obesity in adults with a body mass index (BMI) in excess of 27, so long as they also suffer from weight-related medical issues such as Tupe2 diabestes, high cholesterol and/or hypertension (high blood pressure).Contrave is a combination of two FDA-approved drugs, naltrexone and bupropion, in the extended-release formulation. Naltrexone qualifies to treat alcohol and opioid dependence. Bupropion qualifies to treat depression and seasonal affective disorder in addition to being an aid to smoking cessation treatment.'Obesity remains a major public health concern,' said Jean-Marc Guettier, M.D., director with the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination using a healthy lifestyle that features a reduced-calorie eating and working out, Contrave provides another treatment option for chronic weight reduction for people who are obese or are overweight and have at least one weight-related health.'The drug's effectiveness was evaluated in multiple numerous studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for just one year. All patients received lifestyle modification that contained a reduced- calorie diet and regular exercising. Results from a clinical trial that enrolled patients without diabetes showed that patients had the average weight loss of four years old.1% instead of participants who have been given placebos) throughout a 12- month period, while an outside study involving patients with type 2 diabetes had a normal weight loss of 2% over treatment with placebo at 12 months.

Using two separate drugs to lose weight can be very effective you will find combinations as you're watching FDA now awaiting approval. When dealing with weight-loss and the those who go through it you ought to err along the side of caution and allow the FDA do its job and demand some investigation be done in order that the public recognizes the side effects and dangers of the medications before we drive them. Keep in mind that drug companies are in business to earn money and that they would say almost anything to keep people on their medications.

Researchers found out that participants taking this drug to get a year, lost weight within one month and have kept the extra weight off throughout the 56 weeks with the study. Contrave is a combination from the drugs naltrexone and bupropion, which appears to reflect a fresh trend of weight-loss drugs which are made up of several active ingredient, which can make them far better and safer.

Combo-pilling may be the newest fad or even better the newest in the future under scrutiny and for that reason it is just more publicly known lately, comb-pilling to lose weight has been around since the eighties. The biggest reason that utilizing a combination of pills is becoming popular will be the fact that at the time of right now there aren't long term prescription weight loss supplements that have been approved by the FDA other than orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications even though some of the combinations are actually rejected or have yet to be authorized by the FDA.

Seizures can be a side effect with Contrave and really should not be taken in people with seizure disorders. The drug may also raise blood pressure levels and heartrate, and must not be used in those with a history of cardiac arrest or stroke in the previous six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy while using drug.

The FDA also warned that Contrave can raise blood pressure and heart rate and must not be used in patients with uncontrolled high blood pressure levels, and also by you are not heart-related and cerebrovascular (circulation dysfunction impacting the brain) disease. Patients using a history of cardiac arrest or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes with a boxed warning to alert physicians and patients towards the increased probability of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for stopping smoking.

The most common side effects with Contrave include nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea.